A drug commonly used to treat severe acne can lead to depression-related behavior in mice, according to research published in the journal Neuropsychopharmacology by scientists from The University of Texas at Austin and the University of Bath.
The scientists gave 13-cis-retinoic acid, the active ingredient in Accutane, to mice over six weeks and monitored their behavior.
They found these animals spent significantly more time motionless in a range of behavioral tests compared to untreated animals. Experiments were designed to test the natural escape-related behaviors of the mice in mildly stressful situations.
Mice treated with 13-cis-retinoic acid showed less escape-related behavior than control mice, an indication of depression in these animals.
Accutane belongs to a group of chemicals called retinoids. This group includes vitamin A and vitamin A-related compounds known to affect development of the nervous system. For this reason Accutane is not prescribed to pregnant women
“Retinoids have long been studied for their ability to affect the development of the nervous system,” said Lane, a nutritional scientist whose research focuses on retinoids. “However, new evidence suggests that retinoids can alter the function of the adult brain. For example, there is some evidence that high dietary vitamin A may cause psychiatric symptoms such as hysteria.”
Source from:www.utexas.edu

Depression is a problem that affects both your mind and body and has adverse effects on every part of your life. If it is left untreated, it begins to eat into every part of your life be it your appetite, sleep and even your level of confidence. But this is completely curable and must be correctly diagnosed and treated.

The total of illness due to overweight and obesity in the United States set up those overweight cost U.S. women 1.8 million years of perfect health, compared with just 270,000 years lost for men.
Obesity cost women 3.40 million years of perfect health, compared to 1.94 million years for men. This gender difference could be due to the social stigma that excess weight carries for women but not for men. The study, published in the July issue of the Archives of General Psychiatry, and simultaneously released by EurekAlert, establish that an obese person is about 25 percent more likely than a non-obese person to have a mood or anxiety disorder, such as depression. It also indicated that among Caucasian Americans and more educated people who are obese, that likelihood may be as high as 44 percent.
While the study did not show whether obesity leads to depression or vice versa, "it's almost certain that the association works in both directions," said Greg Simon, MD, MPH, a Group Health psychiatrist and the lead author of the study.

A disease that is affecting millions of people across the globe because of an imbalance in certain chemicals in the brain, called neurotransmitters is known as Depression. Neurotransmitters are the chemicals that allow the nerves of the brain to communicate with each other. It is believed that an imbalance in serotonin, one of these neurotransmitters, is the most important factor in the development and complexity of depression.
Depression- where a person starts getting away from the happiness and the positive aspects of life is a perpetual disease. There have been a number of ways suggested as a cure of Depression like meditation, medication and diversion of ideas. However as this is a chronic disease so a long time medication is required for its cure.

If you have been diagnosed with depression, don’t be alarmed! It can happen to anyone. Be it children, adults or the elderly, depression is hitting every age group! So, don’t think you are alone!
Depression is an emotional disorder that affects your moods, the way you think, your body language and so on! There is a common misconception that people with depression are either ‘over-emotional’ or are going through a ‘bad mood phase’! Depression is something that cannot be wished away. It is a clinical disorder that requires proper treatment.
There are three major types of depression:
Major depression affects the life of a person to a huge extent. It interferes with almost all the activities one performs be it sleeping, eating, studying, working and much more.
Another type of depression is bipolar depression which causes cyclic highs and lows in moods.
The third type is called dysthyma. It is a less severe type of depression that keeps the person from feeling good about himself and also affects his physical function.
Depression can be recognized through a number of symptoms. But most of the people either don’t want to believe that they are affected or they are ignorant. People who suffer from depression experience continuous state of sadness, pessimism and restlessness further added to thoughts of suicide, guilt and worthlessness!
Depression can have a number of causes. It can be caused due to the negative circumstances affecting us or it can simply be genetic. Studies reveal that most people who lack self confidence are prone to depression.
The good news is that depression has a cure! Various antidepressants are available today. Lexapro and Prozac are the most popular ones. They are most prescribed antidepressants in the U.S. These work by increasing the supply of serotonin in the brain. It is a substance that elevates your mood.
Both these drugs are powerful in reducing depression and are well tolerated. Like all drugs, these too have their share of side effects. You might initially experience nausea, insomnia, fatigue, weight gain. But these are only short lived.
But you should be cautious to consult your doctor. Inform him if you have a history of diabetes, kidney disease, manic disorder or any other problem.
Depression is mostly misunderstood. You should not be embarrassed to admit that you are going through it. It is better to treat it than to suffer from it.
It is affecting millions of people around the world! What is required is an emotional and psychological approach to help people overcome the problem!

There are various factors responsible for depression. Some people may have family history of depression and that is inherited generation after generation, whether inherited or not, major depressive disorder is often associated with changes in brain structures or brain function. People who have low self-esteem and always judge himself in the world as the pessimist, he can not believe on himself and lead a stressful life and ultimately become the victim of depression. Sometimes, family conflicts can also be a reason for the depression. That may arise by financial condition, serious loss or damage to the property, sudden change in lifestyle, and unsatisfying sexual relationship among couples. Other major factor for depression is the serious physical ailments. Major health problems like heart attack, stroke, cancer, Parkinson's disease, and hormonal disorders can cause depressive illness because prolonged illness lead to the feeling of irritability and people are unwilling to give adequate attention towards their illness, feeling of sickness may lead them to major depression.

Love is the core of life. Similarly sex is an integral part of happy love life. Love making is termed as the excess of feelings and excitement. Physical pleasure not only gives a physical and mental relief but also an inner poise and a lot of happiness.
Understanding the importance of physical satisfaction and the problems and causes of ED Pfizer Group has come up with the magical tablets – Viagra. Viagra helps and motivates men through different ways.
1. Keeping a stable penis erection.
2. Stimulating an erection when required.
3. Improving the erection time.
4. Enhancing confidence level.
5. Nurturing an exciting and pleasant sexual life.
Viagra starts working within 14 minutes of its consumption. Around 16 million men in US have been using Viagra and approved it for its performance, safety, usage and results. Viagra is the numero uno power increasing tablets. These tablets work by stimulating the nerves which eventually results in a better flow of blood from brain to penis and hence a better and stable erection.

• Major Depression-This is the most dangerous or solemn type of depression, in terms of number of symptoms and severity of symptoms, but there are significant individual differences in the symptoms and severity. You do not need to feel suicidal to have a major depression, and you do not need to have a history of hospitalizations either, although both of these factors are present in some people with major depression. There is no official diagnosis of "moderate depression."
• Dysthymic Disorder- This refers to a low to moderate level of depression that persists for at least two years, and often longer. While the symptoms are not as severe as a major depression, they are more enduring and resistant to treatment. Some people with dysthymia develop a major depression at some time during the course of their depression.
• Unspecified Depression - This category is used to help researchers who are studying other specific types of depression, and do not want their data confounded with marginal diagnoses. It includes people with a serious depression, but not quite severe enough to have a diagnosis of a major depression. It also includes people with chronic, moderate depression, which has not been present long enough for a diagnosis of a Dysthymic disorder.
• Bipolar Depression- This type includes both high and low mood swings, as well as a variety of other significant symptoms not present in other depressions.

Depression - in this non-medical sense - may be caused by a loss or personal failure (as in sadness), personal rejection, or indeed by any undesired outcome or situation, particularly if the situation happens or continues despite the efforts of the subject.Depression, or, more properly, a depressed mood, may in everyday English refer to a state of melancholia, unhappiness or sadness, or to a relatively minor downturn in mood that may last only a few hours or days. A mental disorder marked by altered mood, this may occur daily with the addition of diminished interest or pleasure in most or all activities. Symptoms can be as follows: poor appetite or weight loss, or weight gain, insomnia or hypersomnia, feelings of hopelessness, worthlessness or inappropriate guilt, difficulties with concentration and thinking, and recurrent thoughts of death or suicidal ideations.

Depression signifies the unsteady state of mind. It generally arises in our life due to feeling of insecurity. Most of people often try to be someone else. They constantly crave for having brad pit’s looks, Julia Roberts smile, bill gates bank balance and gorge bush’s power and pride. Instead of knowing their own traits and building upon them, they indulge in doing they cannot do. And the end result is the evil of depression afflicting their lives. What is required? We should accept ourselves as we are. Comparisons are totally illogical. God has gifted each and every one of us something unique. So what required is to know is the things you can be best at and further polishing on them. This will help you in improving and creating a person called “You”.